Archive for April 4th, 2007

Reinventing Wheels: How biological open source licensing works.

April 4th, 2007

Almost all technologies in the life sciences are intertwined and interdependent. Few discoveries stand on their own, and fewer inventions. Not only do they each depend on the pre-existing knowledge base, they almost always incorporate components of many other technologies in their execution.

This is particularly true for tools and technologies that are what I call ‘meta-technologies’, whose effects are broad and that are useful for communities of innovators who are quite distant from the inventor of the tool.

Consider the wheel. It is clearly a tool, and clearly a meta- technology. In some ways, it is the most fundamental and important tool in society, as it has so many uses, unanticipated by its inventor(s). These uses are countless, and they are mostly made by people who are not wheel-builders.

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Neglected Diseased: Telomerase, Cancer, Patents and Poverty

April 4th, 2007

With the welcome attention to ‘neglected diseases’ such as malaria and tuberculosis associated with poverty, there is a tendency to forget the many health challenges such as heart disease, diabetes and cancer which wreak havoc in both worlds. These ‘shared diseases’ have dramatically different markets in both first and third world, and some thoughts about the disparity in options exposes some structural failings and innovation opportunities.

Leaving the development of diagnostics and treatments of such diseases and conditions to market forces, especially when intellectual property can be used to control entry of new players, will continue to render these debilitating but familiar illnesses a sad litany of social inequities. Are there ways that research-intensive solutions can be cooperatively generated that can grapple with this challenge?

More of the world dies of cancer than almost any other single disease. According to the WHO, cancer kills almostCancer Incidence and Mortality seven million people a year of whom about half are in the developing world. By comparison, AIDS-related conditions kill about three million people a year.

In the industrialized world, the availability of diagnostics and therapeutics for cancer, while often outrageously expensive, can lead to very favorable outcomes. In the poorer parts of the world, diagnostic technology, when available, is inadequate to the task, and few therapeutics are affordable. There are literally millions of people who die of cancer each year in the poorer parts of the world, many of whom could have had longer and more productive lives if the diagnostic and therapeutic options available to their rich neighbors were available to them.

With cancer, it is not the disease that is neglected, but the diseased.

Telomerase is an enzyme in human cells which repairs the ends of chromosomes, and is tightly regulated in normal and normally aging cells. However in tumor cells and tissues, telomerase is often wildly de-regulated, rendering such cells virtually immortal. As such, it has been viewed as the platform from which a key ‘silver bullet’ for cancer therapeutics, for diagnostics, for gerontology, even for production of stem cells, could evolve.

This was the focus of a fascinating press piece by Judy Foreman in 2003 called “Telomerase: a promising cancer drug stuck in patent hell?”

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World Congress of Science Journalists

April 4th, 2007

In two weeks – April 19th – I’ll be at another conference in Melbourne, the World Congress of Science Journalists. At that congress, I’ll be producing a session about who benefits from science in a world where virtually every scientific discovery and platform is patented, and the elephant in the room: capability to use science. Phil Campbell, the editor of Nature (the magazine, not the phenomenon) will participate and we hope to expose the journalists to the realities of what’s happened as science becomes fragmented and owned. Few understand the world of patents, fewer still appreciate the profound impacts on our society.

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Mapmakers & mariners, shipwrights & sailors

April 4th, 2007

I made a presentation at the A2K meeting last year called Mapmakers and Mariners, Shipwrights and Sailors. I had prepared it while sitting on the stage listening to the other speakers (my preferred mode of preparation). it was inspired by a conversation I had with a fine journalist named Kenn Cukier.

In that discussion we were exploring the parallels between the intense competition to navigate the oceans during the creation of the European mercantile empires of the 1400-1800s, and the ability to navigatekenn-cukier.jpg the patent world now in the new millennium. In both cases, the proprietary knowledge of the routes, the shoals, the dangers, the currents and the ports was of enormous importance for achieving commercial advantage, and of course economic primacy.

Kenn later went on to write an exceptional piece for Nature Biotechnology about navigating patents in biotechnology, further exploring this metaphor.   In the late 1600’s, the Spanish could risk the Manila Galleon traveling from the far East to Spain via the Pacific Ocean – and many of the annual Galleons sunk – because the reward was so high. The profits on silk, silver and spices were astronomical. Navigation and seamanship would have to be exquisitely well developed to justify smaller profits; simply to drop the risk profile. And indeed over the years, as both cartography and maritime technology improved, so did the volume, quality and reciprocity of trade. And of course it was the tools development that drove the navigational capability: the marine sextant allowed latitude to be calculated, the marine chronometer, the longitude.

It is clear that the ability to see the dangers and opportunities, the detritus and the value within the patent system was going to be critical if science and technology is to achieve a greater social good, especially for small markets or weak market signals – one way to say ‘for the benefit of poor people’.

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Not Access to Knowledge, but Capability to Use Knowledge!

April 4th, 2007

I attended a meeting called A2K (Access To Knowledge) held at Yale last year (Conference Wiki).   I got to hang with some friends whom I admire, like Yochai Benkler (one of the organizers) and to get to know some remarkable people, like Shay David – a clear and articulate thinker who has since visited us in Canberra.

For all the quality at the meeting, I was somewhat disappointed that there was an exclusive focus on ‘making information available’, but no one was talking about the Elephant in the Room, namely the extraordinary restrictions that were developing on the ‘capability to make use of that information’.

It shouldn’t have been surprising I suppose, for a group of academics – for indeed it was pretty much all academics save perhaps me and the janitor – to not be worried about constraints to the creation of tangible economic value – the core of innovation, as it is generally outside of their purview. But it was nonetheless greatly unsettling. I find the simple thought experiment that comes from testing hypotheses in physics to be a useful exercise.

If you’re proposing a course of action, it is instructive to imagine it succeeding (testing the hypothesis at the limit cases), and asking what consequences would eventuate. In the case of universal access to information, let’s imagine all information is available to everyone, everywhere, at no cost. What then?

Well, ultimately there is no impact of that information on our lives until it is ‘converted’ into products or processes. And the ability to ‘convert’ knowledge, what I call the ‘capability to use knowledge’ is associated with barriers, the most prominent one these days being patents. Thus, if you control by patent (or other means) the permissive use of a process of actually making a drug based on some scientific information; or making a crop based on rice genome information; or making a diagnostic for cancer based on clinical data, then you have effectly co-opted and obtained exclusive control over the value of the entire supporting body of ‘public’ information. So that ‘public information’ only there as a publicly funded (or publicly sanctioned) subsidy of the value proposition for those who control its further development into economic outcomes.